Generic Name: Esomeprazole Sodium Injection
Company Name: Radiant Pharmaceuticals Ltd.
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Indication of Exium 40 IV Injection
Exium 40 lessens the quantity of acid your stomach produces. Heartburn, acid reflux, and issues with your food pipe are all treated with it. Stomach ulcers can also be prevented and treated with them. Exium 40 should be taken as prescribed by your doctor.
Pharmacology of Exium 40 IV Injection
By specifically inhibiting the H+/K+ ATPase in the gastric parietal cell, the proton pump inhibitor esomeprazole reduces stomach acid output. The first single optical isomer of a proton pump inhibitor, esomeprazole (S-isomer of omeprazole), offers superior acid control over racemic proton pump inhibitors.
Dosage & Administration
Tablet or Capsule:
Injection:
Interaction of Exium 40 IV Injection
Exium appears to be a selective inhibitor of the cytochrome P450 mono-oxygenase system, there may be an effect on hepatic clearance, but there have been no reports to date of clinically relevant interactions. There is some uncertainty over the effect of Esomeprazole on the oral combined contraceptive pill. Physiological changes similar to those found with omeprazole are likely to take place because of the reduction in gastric acid which is likely to influence the bacterial colonization of the stomach and duodenum and also vitamin B12 absorption.
Contraindications
Esomeprazole is contraindicated in those patients who have known hypersensitivity to any other components of the formulation.
Side Effects of Exium 40 IV Injection
Side effects reported with Exium include:
Pregnancy and lactation
Pregnancy The S-isomer of omeprazole, esomeprazole, has not been adequately studied in pregnant women, and the available epidemiologic data do not support a link between first-trimester omeprazole use and an increased risk of significant congenital abnormalities or other negative pregnancy outcomes. The dosage-dependent embryo-lethality observed in reproduction tests in rats and rabbits occurred at omeprazole doses that ranged from 3.4 to 34 times the 40 mg oral human dose (based on a body surface area for a 60 kg person) There are no clinical studies on the effects of esomeprazole on breastfed infants or milk supply. Esomeprazole is the S-isomer of omeprazole, and limited evidence indicates that omeprazole may be found in human milk.
Along with the mother's clinical requirement for therapy and any potential negative effects on the breastfed child from treatment or from an underlying maternal ailment, the developmental and health benefits of nursing should be taken into consideration.
Precautions & Warnings
Exclude the possibility of malignancy when gastric ulcer is suspected and before treatment for dyspepsia. When used in combination with antibiotics, refer to the prescribing information of the respective antibiotics.
Storage Conditions
Keep in a dry place and away from light and heat. Keep out of the reach of children.
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